![]() ![]() ![]() We generated 12 recommendations, two research statements, and five good practice statements related to modes of ventilation, tidal volume, ventilation pressures, lung-protective ventilation bundles, driving pressure, mechanical power, recruitment maneuvers, prone positioning, and high-frequency ventilation. We identified 26 pediatric studies for inclusion and 36 meta-analyses or systematic reviews in adults. The Grading of Recommendations Assessment, Development and Evaluation approach was used to identify and summarize relevant evidence and develop recommendations, good practice statements and research statements. Title/abstract review, full text review, and data extraction using a standardized data collection form. In addition, meta-analyses and systematic reviews focused on the adult acute respiratory distress syndrome population were included to explore new relevant concepts (e.g., mechanical power, driving pressure, etc.) still underrepresented in the contemporary pediatric literature. We included clinical studies of critically ill patients undergoing invasive mechanical ventilation for PARDS, January 2013 to April 2022. MEDLINE (Ovid), Embase (Elsevier), and CINAHL Complete (EBSCOhost). To provide evidence for the Second Pediatric Acute Lung Injury Consensus Conference updated recommendations and consensus statements for clinical practice and future research on invasive mechanical ventilation support of patients with pediatric acute respiratory distress syndrome (PARDS). 7 Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH.6 Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.5 Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region of Denmark, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.4 Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.3 Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.2 Pediatric Intensive Care Unit, Hospital Universitari, Politecnic La Fe, Valencia, Spain.Durand" Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. 1 Pediatric Intensive Care Unit, Emergency Department, Hospital General de Agudos "C. ![]() Guillaume Emeriaud, Yolanda M López-Fernández, Narayan Prabhu Iyer, Melania M Bembea, Asya Agulnik, Ryan P Barbaro, Florent Baudin, Anoopindar Bhalla, Werther Brunow de Carvahlo, Christopher L Carroll, Ira M Cheifetz, Mohammod J Chisti, Pablo Cruces, Martha A Q Curley, Mary K Dahmer, Heidi J Dalton, Simon J Erickson, Sandrine Essouri, Analía Fernández, Heidi R Flori, Jocelyn R Grunwell, Philippe Jouvet, Elizabeth Y Killien, Martin C J Kneyber, Sapna R Kudchadkar, Steven Kwasi Korang, Jan Hau Lee, Duncan J Macrae, Aline Maddux, Vicent Modesto I Alapont, Brenda Morrow, Vinay M Nadkarni, Natalie Napolitano, Christopher J L Newth, Martí Pons-Odena, Michael W Quasney, Prakadeshwari Rajapreyar, Jerome Rambaud, Adrienne G Randolph, Peter Rimensberger, Courtney M Rowan, L Nelson Sanchez-Pinto, Anil Sapru, Michael Sauthier, Steve L Shein, Lincoln S Smith, Katerine Steffen, Muneyuki Takeuchi, Neal J Thomas, Sze Man Tse, Stacey Valentine, Shan Ward, R Scott Watson, Nadir Yehya, Jerry J Zimmerman, Robinder G Khemani ![]()
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